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This CellML file was generated on 31/07/2008 at 3:02:14 at p.m. using:

COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

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		<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials.</title>
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<article>
  <articleinfo>
  <title>Updated previously modified (with Ito and Irel) Faber and Rudy 2000 model with a corrected description of T-type calcium current </title>
  <author>
     <firstname>Wing Chiu</firstname>
          <surname>Tong</surname>
    <affiliation>
      <shortaffil>Newcastle University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            In this version of the Faber and Rudy 2000 model of a mammalian ventricular cardiomyocyte, the ICaT is reformulated to describe the biophysical characteristics that are more commonly ascribed to this current. The CellML equations are validated using OpenCell and all units are consistent. The model can be run in both OpenCell (version 0.8) and OpenCOR (version 0.4) environments. 
          </para>
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  <sect1 id="sec_structure">
<title>Model Structure</title>
<para> The original formulation of ICaT did not describe the current correctly so we replaced it with a new formulation. All the other model components, and the abstract below, remain the same as <ulink url="https://models.physiomeproject.org/exposure/55643f2114a2a463ada007deb9fc3913/faber_rudy_modified_version_2000.cellml/view">the modified Faber and Rudy 2000 model first translated using the LRd07 Matlab code with the addition of a transient potassium current (Ito) and an updated Irel current</ulink>.  
</para>

<para>ABSTRACT:  Sodium overload of cardiac cells can accompany various pathologies and induce fatal cardiac arrhythmias. We investigate effects of elevated intracellular sodium on the cardiac action potential (AP) and on intracellular calcium using the Luo-Rudy model of a mammalian ventricular myocyte. The results are: 1) During rapid pacing, AP duration (APD) shortens in two phases, a rapid phase without Na(+) accumulation and a slower phase that depends on [Na(+)](i). 2) The rapid APD shortening is due to incomplete deactivation (accumulation) of I(Ks). 3) The slow phase is due to increased repolarizing currents I(NaK) and reverse-mode I(NaCa), secondary to elevated [Na(+)](i). 4) Na(+)-overload slows the rate of AP depolarization, allowing time for greater I(Ca(L)) activation; it also enhances reverse-mode I(NaCa). The resulting increased Ca(2+) influx triggers a greater [Ca(2+)](i) transient. 5) Reverse-mode I(NaCa) alone can trigger Ca(2+) release in a voltage and [Na(+)](i)-dependent manner. 6) During I(NaK) block, Na(+) and Ca(2+) accumulate and APD shortens due to enhanced reverse-mode I(NaCa); contribution of I(K(Na)) to APD shortening is negligible. By slowing AP depolarization (hence velocity) and shortening APD, Na(+)-overload acts to enhance inducibility of reentrant arrhythmias. Shortened APD with elevated [Ca(2+)](i) (secondary to Na(+)-overload) also predisposes the myocardium to arrhythmogenic delayed afterdepolarizations.
</para>

<para>
The references for the papers containing this information are cited below:
</para>

<para>
Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials. Wing-Chiu Tong, Iffath Ghouri and Michael J. Taggart, 2014, Frontiers in Physiology, 5, 399.  <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/25360118">PubMed ID: 25360118</ulink>
</para>
<para>
Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study, Gregory M. Faber and Yoram Rudy, 2000, Biophysical Journal, 78, 2392-2404.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10777735&amp;dopt=Abstract">PubMed ID: 10777735</ulink>
</para>

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<caption>Comparison of the original Faber &amp; Ruddy (2000) (panel A, left hand side) and the new Tong et. al. (2014) (panel A, right hand side) ICaT formulations: simulations of (A) current tracings at different voltage steps and (B) the corresponding I-V plot.</caption>
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<caption>A schematic diagram of the Faber and Rudy 2000 cardiac myocyte model.</caption>
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               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">0.32</cn>
                  <ci>E0_m</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                        </apply>
                        <ci>E0_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00006" name="fast_sodium_current_h_gate">
      <variable initial_value="0.981794631652901" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_ms"/>
      <variable name="beta_h" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.135</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">3.56</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.35</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.13</cn>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00007" name="fast_sodium_current_j_gate">
      <variable initial_value="0.988104917040651" name="j" public_interface="out" units="dimensionless"/>
      <variable name="alpha_j" units="per_ms"/>
      <variable name="beta_j" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">127140</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt_ms">3.474<sep/>-5</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">2.535<sep/>-7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00046" name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00047" name="i_CaCa" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00048" name="i_CaK" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00049" name="i_CaNa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
      <variable initial_value="1" name="gamma_Cai" units="dimensionless"/>
      <variable initial_value="0.341" name="gamma_Cao" units="dimensionless"/>
      <variable cmeta:id="id_00050" name="I_CaCa" units="microA_per_microF"/>
      <variable cmeta:id="id_00051" name="I_CaK" units="microA_per_microF"/>
      <variable cmeta:id="id_00052" name="I_CaNa" units="microA_per_microF"/>
      <variable initial_value="0.00054" name="P_Ca" units="litre_per_farad_millisecond"/>
      <variable initial_value="6.75e-7" name="P_Na" units="litre_per_farad_millisecond"/>
      <variable initial_value="1.93e-7" name="P_K" units="litre_per_farad_millisecond"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable cmeta:id="id_00061" name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable cmeta:id="id_00062" name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_CaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Cai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Na</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_K</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaCa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaNa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaK</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaCa</ci>
               <ci>i_CaK</ci>
               <ci>i_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00053" name="L_type_Ca_channel_d_gate">
      <variable initial_value="6.86847510834054e-06" name="d" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d" units="per_ms"/>
      <variable name="beta_d" units="per_ms"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="E0_d" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>E0_d</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
                  <ci>d_infinity</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>E0_d</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.035</cn>
                  <ci>E0_d</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <divide/>
               <ci>d_infinity</ci>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>d_infinity</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_d</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>d</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_d</ci>
                  <ci>d</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00054" name="L_type_Ca_channel_f_gate">
      <variable initial_value="0.983904806551856" name="f" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f" units="per_ms"/>
      <variable name="beta_f" units="per_ms"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <apply>
               <divide/>
               <ci>f_infinity</ci>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>f_infinity</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_f</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_f</ci>
                  <ci>f</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00055" name="L_type_Ca_channel_f_Ca_gate">
      <variable name="f_Ca" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0006" name="Km_Ca" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cai</ci>
                     <ci>Km_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00056" name="T_type_Ca_channel">
      <variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00057" initial_value="0.056" name="g_CaT" units="milliS_per_microF"/>
      <variable cmeta:id="id_00058" name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="b" private_interface="in" units="dimensionless"/>
      <variable name="g" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00059" name="T_type_Ca_channel_b_gate">
      <variable initial_value="0.00107239754072387" name="b" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="b_inf" units="dimensionless"/>
      <variable name="tau_b" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
		<apply>
			<eq/>
			<ci>b_inf</ci>
			<apply>
				<divide/>
				<cn cellml:units="dimensionless">1.</cn>
				<apply>
					<plus/>
					<cn cellml:units="dimensionless">1.</cn>
					<apply>
						<exp/>
						<apply>
							<divide/>
							<apply>
								<minus/>
								<apply>
									<plus/>
									<ci>V</ci>
									<cn cellml:units="millivolt">50.</cn>
								</apply>
							</apply>
							<cn cellml:units="millivolt">5.</cn>
						</apply>
					</apply>
				</apply>
			</apply>
		</apply>
		<apply>
			<eq/>
			<ci>tau_b</ci>
			<apply>
				<divide/>
				<cn cellml:units="ms">5.</cn>
				<apply>
					<plus/>
					<apply>
						<times/>
						<cn cellml:units="dimensionless">1.068</cn>
						<apply>
							<exp/>
							<apply>
								<divide/>
								<apply>
									<plus/>
									<ci>V</ci>
									<cn cellml:units="millivolt">16.3</cn>
								</apply>
								<cn cellml:units="millivolt">30.</cn>
							</apply>
						</apply>
					</apply>
					<apply>
						<times/>
						<cn cellml:units="dimensionless">1.068</cn>
						<apply>
							<exp/>
							<apply>
								<divide/>
								<apply>
									<minus/>
									<apply>
										<plus/>
										<ci>V</ci>
										<cn cellml:units="millivolt">16.3</cn>
									</apply>
								</apply>
								<cn cellml:units="millivolt">30.</cn>
							</apply>
						</apply>
					</apply>
				</apply>
			</apply>
		</apply>
	    <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_inf</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00060" name="T_type_Ca_channel_g_gate">
      <variable initial_value="0.592188823541168" name="g" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="g_inf" units="dimensionless"/>
      <variable name="tau_g" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
		<apply>
			<eq/>
			<ci>g_inf</ci>
			<apply>
				<divide/>
				<cn cellml:units="dimensionless">1.</cn>
				<apply>
					<plus/>
					<cn cellml:units="dimensionless">1.</cn>
					<apply>
						<exp/>
						<apply>
							<divide/>
							<apply>
								<plus/>
								<ci>V</ci>
								<cn cellml:units="millivolt">61.</cn>
							</apply>
							<cn cellml:units="millivolt">5.</cn>
						</apply>
					</apply>
				</apply>
			</apply>
		</apply>
		<apply>
			<eq/>
			<ci>tau_g</ci>
			<apply>
				<divide/>
				<cn cellml:units="ms">5.</cn>
				<apply>
					<plus/>
					<apply>
						<times/>
						<cn cellml:units="dimensionless">0.015</cn>
						<apply>
							<exp/>
							<apply>
								<divide/>
								<apply>
									<minus/>
									<apply>
										<plus/>
										<ci>V</ci>
										<cn cellml:units="millivolt">71.7</cn>
									</apply>
								</apply>
								<cn cellml:units="millivolt">83.3</cn>
							</apply>
						</apply>
					</apply>
					<apply>
						<times/>
						<cn cellml:units="dimensionless">0.015</cn>
						<apply>
							<exp/>
							<apply>
								<divide/>
								<apply>
									<plus/>
									<ci>V</ci>
									<cn cellml:units="millivolt">71.7</cn>
								</apply>
								<cn cellml:units="millivolt">15.4</cn>
							</apply>
						</apply>
					</apply>
				</apply>
			</apply>
		</apply>
	    <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_inf</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00017" name="rapid_delayed_rectifier_potassium_current">
      <variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00018" name="g_Kr" units="milliS_per_microF"/>
      <variable cmeta:id="id_00019" initial_value="0.02614" name="G_Kr" units="milliS_per_microF"/>
      <variable name="Rect" units="dimensionless"/>
      <variable cmeta:id="id_00020" name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="xr" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <ci>G_Kr</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Rect</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>Rect</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00021" name="rapid_delayed_rectifier_potassium_current_xr_gate">
      <variable initial_value="0.0068050628191769" name="xr" public_interface="out" units="dimensionless"/>
      <variable name="xr_infinity" units="dimensionless"/>
      <variable name="tau_xr" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.123</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00022" name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00023" name="g_Ks" units="milliS_per_microF"/>
      <variable cmeta:id="id_00024" initial_value="0.433" name="G_Ks" units="milliS_per_microF"/>
      <variable cmeta:id="id_00025" name="E_Ks" units="millivolt"/>
      <variable initial_value="0.01833" name="PNaK" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="xs1" private_interface="in" units="dimensionless"/>
      <variable name="xs2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <ci>G_Ks</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millimolar">3.8<sep/>-5</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00026" name="slow_delayed_rectifier_potassium_current_xs1_gate">
      <variable initial_value="0.053484483308799" name="xs1" public_interface="out" units="dimensionless"/>
      <variable name="xs1_infinity" units="dimensionless"/>
      <variable name="tau_xs1" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19<sep/>-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00027" name="slow_delayed_rectifier_potassium_current_xs2_gate">
      <variable initial_value="0.0915338818524544" name="xs2" public_interface="out" units="dimensionless"/>
      <variable name="xs2_infinity" units="dimensionless"/>
      <variable name="tau_xs2" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19<sep/>-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00028" name="ATP_sensitive_potassium_current">
      <variable cmeta:id="ATP_sensitive_potassium_current_i_K_ATP" name="i_K_ATP" public_interface="out" units="microA_per_microF"/>
      <variable name="g_K_ATP" units="milliS_per_microF"/>
      <variable initial_value="1" name="i_K_ATP_on" units="dimensionless"/>
      <variable initial_value="0.24" name="nATP" units="dimensionless"/>
      <variable initial_value="5e-5" name="nicholsarea" units="dimensionless"/>
      <variable initial_value="3" name="ATPi" units="millimolar"/>
      <variable initial_value="2" name="hATP" units="dimensionless"/>
      <variable initial_value="0.00025" name="kATP" units="millimolar"/>
      <variable name="pATP" units="dimensionless"/>
      <variable name="GKbaraATP" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_ATP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_K_ATP_on</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.000193</cn>
               </apply>
               <ci>nicholsarea</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pATP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <ci>kATP</ci>
                     </apply>
                     <ci>hATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GKbaraATP</ci>
            <apply>
               <times/>
               <ci>g_K_ATP</ci>
               <ci>pATP</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">4</cn>
                  </apply>
                  <ci>nATP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_ATP</ci>
            <apply>
               <times/>
               <ci>GKbaraATP</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00096" name="transient_outward_current">
      <variable cmeta:id="transient_outward_current_i_to" name="i_to" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00097" name="g_to" units="milliS_per_microF"/>
      <variable cmeta:id="id_00098" name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="rvdv" units="dimensionless"/>
      <variable name="zdv" private_interface="in" units="dimensionless"/>
      <variable name="ydv" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rvdv</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>zdv</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ydv</ci>
               <ci>rvdv</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00099" name="transient_outward_current_zdv_gate">
      <variable initial_value="0.0153950987302045" name="zdv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_zdv" units="per_ms"/>
      <variable name="beta_zdv" units="per_ms"/>
      <variable name="tau_zdv" units="ms"/>
      <variable name="zdv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_zdv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>zdv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_zdv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>zdv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>zdv_ss</ci>
                  <ci>zdv</ci>
               </apply>
               <ci>tau_zdv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00100" name="transient_outward_current_ydv_gate">
      <variable initial_value="0.931914460539262" name="ydv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_ydv" units="per_ms"/>
      <variable name="beta_ydv" units="per_ms"/>
      <variable name="tau_ydv" units="ms"/>
      <variable name="ydv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.015</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ydv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ydv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_ydv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ydv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ydv_ss</ci>
                  <ci>ydv</ci>
               </apply>
               <ci>tau_ydv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00040" name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="microA_per_microF"/>
      <variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
      <variable name="g_K1" units="milliS_per_microF"/>
      <variable initial_value="0.75" name="G_K1" units="milliS_per_microF"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="K1_infinity" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>G_K1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00039" name="time_independent_potassium_current_K1_gate">
      <variable name="K1_infinity" public_interface="out" units="dimensionless"/>
      <variable name="alpha_K1" units="per_ms"/>
      <variable name="beta_K1" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.49124</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08032</cn>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.476</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">594.31</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00029" name="plateau_potassium_current">
      <variable cmeta:id="plateau_potassium_current_i_Kp" name="i_Kp" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00030" initial_value="0.00552" name="g_Kp" units="milliS_per_microF"/>
      <variable cmeta:id="id_00031" name="Kp" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable cmeta:id="id_00032" name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00101" name="sodium_activated_potassium_current">
      <variable cmeta:id="sodium_activated_potassium_current_i_K_Na" name="i_K_Na" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.12848" name="g_K_Na" units="milliS_per_microF"/>
      <variable initial_value="2.8" name="nKNa" units="dimensionless"/>
      <variable name="pona" units="dimensionless"/>
      <variable name="pov" units="dimensionless"/>
      <variable initial_value="66" name="kdKNa" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>pona</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.85</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>kdKNa</ci>
                        <ci>Nai</ci>
                     </apply>
                     <ci>nKNa</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pov</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.65</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">125</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_Na</ci>
            <apply>
               <times/>
               <ci>g_K_Na</ci>
               <ci>pona</ci>
               <ci>pov</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00084" name="sarcolemmal_calcium_pump">
      <variable cmeta:id="sarcolemmal_calcium_pump_i_p_Ca" name="i_p_Ca" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00085" initial_value="0.0005" name="K_mpCa" units="millimolar"/>
      <variable cmeta:id="id_00086" initial_value="1.15" name="I_pCa" units="microA_per_microF"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00008" name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_Na_b" name="i_Na_b" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00068" initial_value="0.004" name="g_Nab" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable cmeta:id="id_00069" name="E_Na" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00063" name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_Ca_b" name="i_Ca_b" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00064" initial_value="0.003016" name="g_Cab" units="milliS_per_microF"/>
      <variable cmeta:id="id_00065" name="E_Ca" public_interface="out" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable cmeta:id="id_00070" name="Cai" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00071" name="Cao" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00079" name="sodium_potassium_pump">
      <variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00080" initial_value="2.25" name="I_NaK" units="microA_per_microF"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable initial_value="10" name="K_mNai" units="millimolar"/>
      <variable initial_value="1.5" name="K_mKo" units="millimolar"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable cmeta:id="id_00081" name="Nai" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00082" name="Nao" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00083" name="Ko" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>I_NaK</ci>
                     <ci>f_NaK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>K_mNai</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>K_mKo</ci>
                     <ci>Ko</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00072" name="non_specific_calcium_activated_current">
      <variable cmeta:id="non_specific_calcium_activated_current_i_ns_Ca" name="i_ns_Ca" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00073" name="i_ns_Na" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00074" name="i_ns_K" public_interface="out" units="microA_per_microF"/>
      <variable cmeta:id="id_00075" name="P_ns_Ca" units="litre_per_farad_millisecond"/>
      <variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00078" name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00077" name="Ki" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00075" name="I_ns_Na" units="microA_per_microF"/>
      <variable cmeta:id="id_00076" name="I_ns_K" units="microA_per_microF"/>
      <variable initial_value="0.0012" name="K_m_ns_Ca" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>P_ns_Ca</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_millisecond">1.75<sep/>-7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00087" name="Na_Ca_exchanger">
      <variable cmeta:id="Na_Ca_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.00025" name="c1" units="microA_per_microF"/>
      <variable initial_value="0.0001" name="c2" units="dimensionless"/>
      <variable initial_value="0.15" name="gamma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable cmeta:id="id_00088" name="Nai" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00089" name="Nao" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00090" name="Cai" public_interface="in" units="millimolar"/>
      <variable cmeta:id="id_00091" name="Cao" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>c1</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>gamma</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <power/>
                           <ci>Nao</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <ci>c2</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>gamma</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cao</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nao</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00092" name="calcium_dynamics">
      <variable name="i_rel" public_interface="in" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_up" name="i_up" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_leak" name="i_leak" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_tr" name="i_tr" public_interface="out" units="millimolar_per_ms"/>
      <variable initial_value="120" name="tau_tr" units="ms"/>
      <variable initial_value="10" name="CSQN_max" units="millimolar"/>
      <variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
      <variable initial_value="0.00092" name="K_mup" units="millimolar"/>
      <variable name="K_leak" units="per_ms"/>
      <variable initial_value="0.00875" name="I_up" units="millimolar_per_ms"/>
      <variable initial_value="15" name="Ca_NSR_max" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable initial_value="0.0354676562409019" name="CaT" public_interface="out" units="millimolar"/>
      <variable initial_value="1.8" name="Cao" public_interface="out" units="millimolar"/>
      <variable name="Ca_JSR" public_interface="out" units="millimolar"/>
      <variable initial_value="7.64464040842916" name="JSR" public_interface="out" units="millimolar"/>
      <variable initial_value="3.35408001677624" name="NSR" public_interface="out" units="millimolar"/>
      <variable name="Cai" public_interface="out" units="millimolar"/>
      <variable name="bjsr" public_interface="out" units="millimolar"/>
      <variable name="cjsr" public_interface="out" units="millimolar2"/>
      <variable name="bmyo" public_interface="out" units="millimolar"/>
      <variable name="cmyo" public_interface="out" units="millimolar2"/>
      <variable name="dmyo" public_interface="out" units="millimolar3"/>
      <variable name="V_myo" public_interface="in" units="micro_litre"/>
      <variable name="A_cap" public_interface="in" units="cm2"/>
      <variable name="V_JSR" public_interface="in" units="micro_litre"/>
      <variable name="V_NSR" public_interface="in" units="micro_litre"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="K_mTRPN" units="millimolar"/>
      <variable initial_value="0.00238" name="K_mCMDN" units="millimolar"/>
      <variable initial_value="0.07" name="TRPN_max" units="millimolar"/>
      <variable initial_value="0.05" name="CMDN_max" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>bjsr</ci>
            <apply>
               <plus/>
               <ci>CSQN_max</ci>
               <ci>K_mCSQN</ci>
               <apply>
                  <minus/>
                  <ci>JSR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cjsr</ci>
            <apply>
               <times/>
               <ci>K_mCSQN</ci>
               <ci>JSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_JSR</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <root/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>bjsr</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>cjsr</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>bjsr</ci>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bmyo</ci>
            <apply>
               <plus/>
               <ci>CMDN_max</ci>
               <ci>TRPN_max</ci>
               <ci>K_mCMDN</ci>
               <ci>K_mTRPN</ci>
               <apply>
                  <minus/>
                  <ci>CaT</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cmyo</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>K_mCMDN</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>TRPN_max</ci>
                  <ci>K_mCMDN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CMDN_max</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>CaT</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>K_mTRPN</ci>
                     <ci>K_mCMDN</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmyo</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>K_mTRPN</ci>
               </apply>
               <ci>K_mCMDN</ci>
               <ci>CaT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Cai</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <root/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <ci>bmyo</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>cmyo</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <cos/>
                     <apply>
                        <divide/>
                        <apply>
                           <arccos/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9</cn>
                                    <ci>bmyo</ci>
                                    <ci>cmyo</ci>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                       <apply>
                                          <power/>
                                          <ci>bmyo</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">27</cn>
                                       <ci>dmyo</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <apply>
                                    <root/>
                                    <apply>
                                       <power/>
                                       <apply>
                                          <minus/>
                                          <apply>
                                             <power/>
                                             <ci>bmyo</ci>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                          </apply>
                                          <apply>
                                             <times/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                             <ci>cmyo</ci>
                                          </apply>
                                       </apply>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>bmyo</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Cai</ci>
                  <ci>K_mup</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_leak</ci>
            <apply>
               <divide/>
               <ci>I_up</ci>
               <ci>Ca_NSR_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>K_leak</ci>
               <ci>NSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>JSR</ci>
            </apply>
            <apply>
               <minus/>
               <ci>i_tr</ci>
               <ci>i_rel</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>NSR</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_tr</ci>
                        </apply>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>i_leak</ci>
               </apply>
               <ci>i_up</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaT</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                     </apply>
                     <ci>A_cap</ci>
                     <apply>
                        <plus/>
                        <ci>i_CaCa</ci>
                        <ci>i_Ca_T</ci>
                        <ci>i_p_Ca</ci>
                        <ci>i_Ca_b</ci>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>V_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>i_rel</ci>
                     <ci>V_JSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>i_leak</ci>
                        <ci>i_up</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00066" name="CICR_current">
      <variable initial_value="0.125" name="kappa" units="mM_per_millivolt_ms"/>
      <variable initial_value="4.75" name="tau" units="ms"/>
      <variable initial_value="1" name="K_relss" units="millimolar"/>
      <variable initial_value="9" name="qn" units="dimensionless"/>
      <variable name="alpha_rel" public_interface="out" units="millimolar_per_mV"/>
      <variable name="tau_rel" public_interface="out" units="ms"/>
      <variable name="I_relss" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="CICR_current_i_rel" initial_value="0.000948968144034608" name="i_rel" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="id_00067" name="i_CaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="Ca_JSR" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_rel</ci>
            <apply>
               <times/>
               <ci>kappa</ci>
               <ci>tau</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_relss</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_CaCa</ci>
                  <ci>alpha_rel</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_relss</ci>
                        <ci>Ca_JSR</ci>
                     </apply>
                     <ci>qn</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_rel</ci>
            <apply>
               <divide/>
               <ci>tau</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0123</cn>
                     <ci>Ca_JSR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>i_rel</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>I_relss</ci>
                     <ci>i_rel</ci>
                  </apply>
               </apply>
               <ci>tau_rel</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00093" name="ionic_concentrations">
      <variable cmeta:id="id_00094" initial_value="17.6117490445233" name="Nai" public_interface="out" units="millimolar"/>
      <variable cmeta:id="id_00095" initial_value="140" name="Nao" public_interface="out" units="millimolar"/>
      <variable cmeta:id="id_00105" initial_value="136.516534944494" name="Ki" public_interface="out" units="millimolar"/>
      <variable cmeta:id="id_00106" initial_value="5.4" name="Ko" public_interface="out" units="millimolar"/>
      <variable name="A_cap" public_interface="in" units="cm2"/>
      <variable name="V_myo" public_interface="in" units="micro_litre"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable cmeta:id="id_00009" name="i_Na" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00102" name="i_CaNa" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00010" name="i_Na_b" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00011" name="i_ns_Na" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00103" name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00104" name="i_NaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaK" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00033" name="i_Kr" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00034" name="i_Ks" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00035" name="i_K1" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00036" name="i_Kp" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_Na" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00037" name="i_ns_K" public_interface="in" units="microA_per_microF"/>
      <variable name="I_st" public_interface="in" units="microA_per_microF"/>
      <variable cmeta:id="id_00038" name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to" public_interface="in" units="microA_per_microF"/>
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_Na</ci>
                     <ci>i_CaNa</ci>
                     <ci>i_Na_b</ci>
                     <ci>i_ns_Na</ci>
                     <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>I_st</ci>
                     <ci>i_CaK</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_K1</ci>
                     <ci>i_K_ATP</ci>
                     <ci>i_to</ci>
					 <ci>i_Kp</ci>
                     <ci>i_K_Na</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="geometry">
      <variable initial_value="0.1" name="preplength" units="mm"/>
      <variable initial_value="0.011" name="radius" units="mm"/>
      <variable name="volume" units="micro_litre"/>
      <variable name="V_myo" public_interface="out" units="micro_litre"/>
      <variable name="V_JSR" public_interface="out" units="micro_litre"/>
      <variable name="V_NSR" public_interface="out" units="micro_litre"/>
      <variable initial_value="1.534e-4" name="A_cap" public_interface="out" units="cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>volume</ci>
            <apply>
               <times/>
               <pi/>
               <ci>preplength</ci>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_myo</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0048</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0552</cn>
               <ci>volume</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transmembrane_currents"/>
   <component name="intracellular_currents"/>
   <component name="Ions_n_reversal_potentials"/>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="cell">
         <component_ref component="geometry"/>
         <component_ref component="transmembrane_currents">
            <component_ref component="fast_sodium_current">
               <component_ref component="fast_sodium_current_m_gate"/>
               <component_ref component="fast_sodium_current_h_gate"/>
               <component_ref component="fast_sodium_current_j_gate"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
               <component_ref component="L_type_Ca_channel_d_gate"/>
               <component_ref component="L_type_Ca_channel_f_gate"/>
               <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
               <component_ref component="T_type_Ca_channel_b_gate"/>
               <component_ref component="T_type_Ca_channel_g_gate"/>
            </component_ref>
            <component_ref component="rapid_delayed_rectifier_potassium_current">
               <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
            </component_ref>
            <component_ref component="slow_delayed_rectifier_potassium_current">
               <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
               <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
               <component_ref component="time_independent_potassium_current_K1_gate"/>
            </component_ref>
			<component_ref component="transient_outward_current">
               <component_ref component="transient_outward_current_zdv_gate"/>
               <component_ref component="transient_outward_current_ydv_gate"/>
            </component_ref>
            <component_ref component="Na_Ca_exchanger"/>
            <component_ref component="plateau_potassium_current"/>
            <component_ref component="sodium_activated_potassium_current"/>
            <component_ref component="ATP_sensitive_potassium_current"/>
			<component_ref component="sodium_background_current"/>
            <component_ref component="calcium_background_current"/>
            <component_ref component="sodium_potassium_pump"/>
            <component_ref component="non_specific_calcium_activated_current"/>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="sarcolemmal_calcium_pump"/>
         </component_ref>
         <component_ref component="Ions_n_reversal_potentials">
            <component_ref component="ionic_concentrations"/>
            <component_ref component="calcium_dynamics"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_b_gate"/>
         <component_ref component="T_type_Ca_channel_g_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_potassium_current">
         <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_potassium_current">
         <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
         <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
	  <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_zdv_gate"/>
         <component_ref component="transient_outward_current_ydv_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="cell" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="CICR_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="ATP_sensitive_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="transient_outward_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sodium_activated_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_Na" variable_2="i_K_Na"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="Na_Ca_exchanger"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="plateau_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sarcolemmal_calcium_pump"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sodium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="calcium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
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   <connection>
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